Prevention of diabetes requires above all adherence to certain dietary and physical activity dose, which must maintain a normal body weight. It is known that overweight and obesity is a major risk factors for development of diabetes, especially in the presence of family history.
The risk is even higher for individuals where there is a genetically determined reduced sensitivity of muscle and other peripheral tissues to their own insulin. These cases relate to the so-called. metabolic syndrome / syndrome X / characterized by obesity, elevated blood pressure and hiperinsunilizam – increased secretion of insulin by kompensoren mechanism. In parallel, the insulin response to various food stimuli is disturbed – that is fun, and this leads to high blood sugar after food intake that contribute to damage to the insulin secreting cells of the pancreas at a later stage their functional reserves are depleted .
There are drugs that respond favorably peripheral insulin resistance by lowering blood glucose and insulin hypersecretion. The most frequently used ones are related to the group of bigvandinite, especially metformin preparations available in tablet form. They offer not only for the treatment of type 2 diabetes, but also in patients with impaired glucose tolerance / prediabetes /, as well as in individuals with metabolic syndrome, and hyperinsulinemia without manifest diabetes. In the latter case, the aim is to reduce weight and to overcome the insulin resistance occurring major risk factors for development of diabetes at a later stage.
New perspectives in this regard detect and nyakoimedikamentozni agents that inhibit the degradation of incretins, increasing their blood levels. The incretins are hormones which are secreted in the gastrointestinal tract in food intake. It was found that they enhance glucose-insulin response and inhibit glucagon secretion / pancreatic hormone that increases blood sugar /. Furthermore they possess an extremely important effect – preserving the vitality of beta – cells in the pancreas, they suppress their apoptosis / cell death /. In the advanced stage is the application of such preparations in patients with type 2 diabetes, with very good effect on metabolic parameters and excellent tolerability.
Most important for diabetes prevention and delay of progression is rational nutritional and physical regime appropriate to the age and profession of the person concerned.
Prevention of diabetes also requires active treatment of concomitant diseases that may contribute to its manifestation. Among them are many endocrine diseases – thyrotoxicosis, acromegaly, Cushing’s disease. Particular attention is required to the persons who are treated with cortisone preparations on various chronic diseases. Administration of preparations from the group of metformin in them is relatively contraindicated.